21 Mar 2018 Sacox® microGranulates, containing salinomycin sodium (SAL-Na), for chickens for fattening and chickens reared for laying have been  Salinomycin can induce massive apoptosis in human cancer cells of different origin that display multiple mechanisms of drug and apoptosis resistance. Cell Data  Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. action of salinomycin. Salinomycin shows cyto- toxic effect by disrupting the balance of sodium and potas- sium ions across the cell membrane and the  Visit ChemicalBook To find more Salinomycin(53003-10-4) information like chemical properties,Structure,melting point,boiling point,density,molecular formula  “To investigate its action, we developed a surrogate salinomycin drug, ironomycin, that was at least 10-fold more potent than salinomycin against CSCs in vitro and  Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Salinomycin (Procoxacin)，一种钾离子载体抗生素，选择性抑制革兰氏阳性菌的 生长(gram-positive bacteria)。Salinomycin 是Wnt/β-catenin 信号传导的有效抑制   Vetbiochem India Private Limited - Offering Salinomycin (coccidoline-s), Packaging Type: Bag in Pune, Maharashtra. Get best price and read about company.

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Salinomycin is a membrane ionophore, which shows affinity for alkali ions, preferentially for potassium ions. 2 Salinomycin eases the ion flux through cytoplasmic membrane and the mitochondrial membrane. Salinomycin (SAL) is a veterinary antibiotic used to treat coccidiosis in chicken for more than 30 years (Naujokat et al., 2010). It came on the center stage in cancer drug studies after the revelation of its ability to specifically kill cancer stem cells (CSCs) (Gupta et al., 2009). Niclosamide and salinomycin prevented viral production at low and high doses, while clofazimine was 10-fold less potent than the other two drugs.

Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation.

Salinomycin in är endast tillåtet i vissa fjäderfäfoder och kan vara skadligt för andra djurslag. Salinomycin is an ionophore, also marketed as a coccidiostat, which is related more closely to monensin than is lasalocid.

A recent market study throws light on some of the leading factors that are likely to influence the growth of the Salinomycin Premix market in the upcoming decade.

Salinomycin-induced apoptosis is independent of tumor suppressor protein p53, caspase activation, the CD95/CD95 ligand system, and the proteasome. Salinomycin fails to induce apoptosis in normal human peripheral CD4+ T lymphocytes. 2011-06-02 · Salinomycin is a polyether antibiotic with properties of an ionophore, which is commonly used as cocciodiostatic drug and has been shown to be highly effective in the elimination of cancer stem Salinomycin sodium, Sodium salinomycin: SMILES: CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C(=O)O.[Na+] Storage: Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months.
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The monensin caused anorexia within 36 hours and difficulty rising 72 hours after feeding. In the salinomycin camel, CK rose to 2580 U/L at 48 hours and 146,000 U/L after 8 days. The monensin-fed camel had CK of 459 U/L on day 5 and 53,900 U/L on day 8.

At last,Salinomycin(53003 … White to slightly yellow lyophilizated powder. Purity by HPLC: ≥98% ; refer to CoA for more data 2019-11-25 Salinomycin Sodium (syn: Coxistal, Coxistac) is the sodium salt of Salinomycin, a carboxylic polyether ionophore isolated from Streptomyces albus that has been widely used as an agricultural antibiotic to prevent coccidiosis in poultry. Salinomycin was first isolated in 1974 by the research division of Kaken Chemical Co. in Tokyo Japan. The salinomycin induced anorexia, ataxia, and difficulty rising within 36 hours.
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The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials.

Salinomycin is used in chicken feed as a coccidiostat. Biosynthesis Salinomycin är en fodertillsats av gruppen koccidiostatika som ämnen avsedda att döda eller hindra tillväxten av parasitiska protozoer (encelliga organismer). Salinomycin in är endast tillåtet i vissa fjäderfäfoder och kan vara skadligt för andra djurslag.

Print infocard. Substance identity Substance identity. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. 2 hours ago salinomycin/kg salinomycin sodium. — ≤ 10 g 20- desoxysalinomycin/kg salinomycin sodium. — ≤ 10 g 18,19- dihydrosalinomycin/kg salinomycin sodium. — ≤ 10 g methylated salinomycin/kg salinomycin sodium.